Cassane diterpenoids with α-glucosidase inhibitory activity from the fruits of Pterolobium macropterum

• Sarot Cheenpracha,
• Ratchanaporn Chokchaisiri,
• Lucksagoon Ganranoo,
• Sareeya Bureekaew,
• Thunwadee Limtharakul and
• Surat Laphookhieo

Beilstein J. Org. Chem. 2023, 19, 658–665, doi:10.3762/bjoc.19.47

• -hydroxycassa-11(12),13(15)-dien-12,16-olide (1) and 6′-acetoxypterolobirin B (3), together with a known analogue, identified as 12α,14β-dihydroxycassa-13(15)-en-12,16-olide (2), were isolated from the fruits of Pterolobium macropterum. Compound 1 is a cassane diterpenoid with a Δ11(12) double bond conjugated

• of isolated compounds was evaluated, and compounds 1 and 3 showed significant α-glucosidase inhibitory activity with IC50 values of 66 and 44 μM. Keywords: α-glucosidase inhibitory activity; cassane diterpenoid; Fabaceae; medicinal plant; Pterolobium macropterum; Introduction Diabetes mellitus is a

• ]. Pterolobium macropterum Kurz is a woody climbing shrub that is mainly distributed in the northern Thailand. Its roots are used in the medicinal plant therapy to treat toothache, fever, and to promote wound healing [11]. Previous phytochemical investigations of P. macropterum have revealed that this plant is a